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Pituitary carcinoma

MedGen UID:
91096
•Concept ID:
C0346300
•
Neoplastic Process
Synonyms: Cancer of Pituitary; Cancer of the Pituitary; Cancer, Pituitary; Cancers, Pituitary; Carcinoma, Pituitary; Carcinomas, Pituitary; Pituitary Cancer; Pituitary Cancers; Pituitary Carcinoma; Pituitary Carcinomas
SNOMED CT: Pituitary carcinoma (128665000); Pituitary carcinoma (254955001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
HPO: HP:0011763
Monarch Initiative: MONDO:0017582
Orphanet: ORPHA300385

Definition

A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS. [from HPO]

Professional guidelines

PubMed

Efficacy and safety of temozolomide in the treatment of aggressive pituitary neuroendocrine tumours in Spain.
Lamas C, Cámara R, Fajardo C, Remon-Ruiz P, Biagetti B, Guerrero-Pérez F, Araujo-Castro M, Mora M, Hanzu F, Iglesias P, García-Centeno R, Soto A
Front Endocrinol (Lausanne) 2023;14:1204206. Epub 2023 Aug 31 doi: 10.3389/fendo.2023.1204206. PMID: 37720528Free PMC Article
The treatment of aggressive prolactinomas with everolimus.
Lin AL, Geer EB, Lala N, Page-Wilson G, Magge R, Young RJ, Tabar V
Pituitary 2023 Aug;26(4):474-481. Epub 2023 Jul 10 doi: 10.1007/s11102-023-01340-5. PMID: 37428396Free PMC Article
European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas.
Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J, Dekkers OM; European Society of Endocrinology
Eur J Endocrinol 2018 Jan;178(1):G1-G24. Epub 2017 Oct 18 doi: 10.1530/EJE-17-0796. PMID: 29046323

Recent clinical studies

Etiology

The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Stereotactic Radiosurgery for Pituitary Carcinoma.
Mehta GU, McCutcheon IE
Acta Neurochir Suppl 2021;128:43-49. doi: 10.1007/978-3-030-69217-9_5. PMID: 34191060
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma).
Lenders N, McCormack A
Pituitary 2018 Apr;21(2):217-229. doi: 10.1007/s11102-017-0857-z. PMID: 29299820
Invasive, atypical and aggressive pituitary adenomas and carcinomas.
Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646

Diagnosis

The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas.
Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J, Dekkers OM; European Society of Endocrinology
Eur J Endocrinol 2018 Jan;178(1):G1-G24. Epub 2017 Oct 18 doi: 10.1530/EJE-17-0796. PMID: 29046323
Pituitary carcinoma.
Sansur CA, Oldfield EH
Semin Oncol 2010 Dec;37(6):591-3. doi: 10.1053/j.seminoncol.2010.10.012. PMID: 21167378

Therapy

Medical therapy for refractory pituitary adenomas.
Geer EB
Pituitary 2023 Jun;26(3):303-306. Epub 2023 Apr 28 doi: 10.1007/s11102-023-01320-9. PMID: 37115295
Temozolomide in aggressive pituitary tumours and pituitary carcinomas.
McCormack A
Best Pract Res Clin Endocrinol Metab 2022 Dec;36(6):101713. Epub 2022 Oct 13 doi: 10.1016/j.beem.2022.101713. PMID: 36274026
Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Aggressive pituitary tumours and pituitary carcinomas.
Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834
Aggressive prolactinomas: how to manage?
Lasolle H, Ilie MD, Raverot G
Pituitary 2020 Feb;23(1):70-77. doi: 10.1007/s11102-019-01000-7. PMID: 31617128

Prognosis

The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Aggressive pituitary tumours and pituitary carcinomas.
Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834
Aggressive Pituitary Adenomas and Carcinomas.
Ilie MD, Jouanneau E, Raverot G
Endocrinol Metab Clin North Am 2020 Sep;49(3):505-515. Epub 2020 Jul 8 doi: 10.1016/j.ecl.2020.05.008. PMID: 32741485
Pituitary carcinomas.
Colao A, Ochoa AS, Auriemma RS, Faggiano A, Pivonello R, Lombardi G
Front Horm Res 2010;38:94-108. Epub 2010 Jul 5 doi: 10.1159/000318499. PMID: 20616500

Clinical prediction guides

Therapeutic targeting of the pituitary tumor microenvironment.
Ilie MD, De Alcubierre D, Carretti AL, Jouanneau E, Raverot G
Pharmacol Ther 2023 Oct;250:108506. Epub 2023 Aug 9 doi: 10.1016/j.pharmthera.2023.108506. PMID: 37562699
The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Pituitary carcinoma - case series and review of the literature.
Du Four S, Van Der Veken J, Duerinck J, Vermeulen E, Andreescu CE, Bruneau M, Neyns B, Velthoven V, Velkeniers B
Front Endocrinol (Lausanne) 2022;13:968692. Epub 2022 Sep 8 doi: 10.3389/fendo.2022.968692. PMID: 36157469Free PMC Article
Aggressive pituitary tumours and pituitary carcinomas.
Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834
Aggressive Pituitary Adenomas and Carcinomas.
Ilie MD, Jouanneau E, Raverot G
Endocrinol Metab Clin North Am 2020 Sep;49(3):505-515. Epub 2020 Jul 8 doi: 10.1016/j.ecl.2020.05.008. PMID: 32741485

Recent systematic reviews

Metastatic pituitary tumors: an institutional case series.
Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025
Outcome and prognostic factors for pituitary carcinomas: lessons from a systematic review.
Raymond P, Raverot G, Ilie MD
Endocr Relat Cancer 2023 May 1;30(5) Epub 2023 Mar 31 doi: 10.1530/ERC-22-0338. PMID: 36852675
Immunotherapy in aggressive pituitary tumors and carcinomas: a systematic review.
Ilie MD, Vasiljevic A, Jouanneau E, Raverot G
Endocr Relat Cancer 2022 May 27;29(7):415-426. doi: 10.1530/ERC-22-0037. PMID: 35521777
Immune-checkpoint inhibitors in pituitary malignancies.
Di Nunno V, Franceschi E, Tosoni A, Gatto L, Maggio I, Lodi R, Bartolini S, Brandes AA
Anticancer Drugs 2022 Jan 1;33(1):e28-e35. doi: 10.1097/CAD.0000000000001157. PMID: 34348358
Genetic aspects of pituitary carcinoma: A systematic review.
Yang Z, Zhang T, Gao H
Medicine (Baltimore) 2016 Nov;95(47):e5268. doi: 10.1097/MD.0000000000005268. PMID: 27893664Free PMC Article

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